CHEMISTRY: Diverse Scaffolds
نویسندگان
چکیده
منابع مشابه
Diaminoterephthalates: scaffolds for combinatorial chemistry.
Fluorescent building blocks: Tetracarboxyamides with a central fluorescent diaminoterephthalate unit were prepared from succinyl succinates following a combinatorial-like strategy. The 2,5-diaminoterephthalates (see scheme; PG=protecting group) possess four points of diversification and are introduced as new scaffolds for combinatorial chemistry.2,5-Diaminoterephthalates that possess four point...
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Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. All high-throughput malaria drug discovery efforts have focused on the cyclic blood stage, which has limited potential for the prophylaxis, transmission blocking, and eradication efforts that will be needed in the future. To address these unmet needs, a high-throughput phenotypi...
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Examination of nature's favorite molecules reveals a striking preference for making carbon-heteroatom bonds over carbon-carbon bonds-surely no surprise given that carbon dioxide is nature's starting material and that most reactions are performed in water. Nucleic acids, proteins, and polysaccharides are condensation polymers of small subunits stitched together by carbon-heteroatom bonds. Even t...
متن کاملComputational design of new molecular scaffolds for medicinal chemistry, part II: generalization of analog series-based scaffolds
Aim Extending and generalizing the computational concept of analog series-based (ASB) scaffolds. Materials & methods Methodological modifications were introduced to further increase the coverage of analog series (ASs) and compounds by ASB scaffolds. From bioactive compounds, ASs were systematically extracted and second-generation ASB scaffolds isolated. Results More than 20,000 second-gener...
متن کاملAnalog series-based scaffolds: computational design and exploration of a new type of molecular scaffolds for medicinal chemistry
AIM Computational design of and systematic search for a new type of molecular scaffolds termed analog series-based scaffolds. MATERIALS & METHODS From currently available bioactive compounds, analog series were systematically extracted, key compounds identified and new scaffolds isolated from them. RESULTS Using our computational approach, more than 12,000 scaffolds were extracted from bioa...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.323.5910.17a